“In terms of their mutations, BA.4 and BA.5 share mutations across their genomes with both BA.1 and BA.2 (also lineages of Omicron), but are most similar to BA.2,” says NICD, and provides, “BA.4 and BA.5 differ from one another in mutations that are outside of the spike gene but they are identical to each other in terms of spike mutations (1,2). For this reason, they are often discussed together.”
Whereas the BA.4 was first detected from a specimen collected on 10 January 2022 in Limpopo, the BA.5 Omicron lineage was first noticed from a specimen collected on 25 February 2022 in KwaZulu-Natal.
Each lineages have been detected in international locations exterior South Africa, such because the USA, UK, and Botswana.
As per stories, on Might 9 particulars of BA.4 subvariant had been entered on GISAID by India. Scientists related to the Indian SARS-CoV-2 Consortium on Genomics (INSACOG) have confirmed this to the media.